Drug interactions
Dronedarone + Timolol
Severity: Moderate
Dronedarone and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP2D6 and also has beta-blocking and negative chronotropic properties. Combined with timolol it may raise beta-blocker exposure and increase the risk of bradycardia, AV block and hypotension.
What this interaction means in plain words
Dronedarone and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
CYP2D6 inhibition by dronedarone plus additive negative chronotropic and dromotropic effects.
What to do
Start with a low beta-blocker dose and obtain an ECG to check for bradycardia or conduction delay. Adjust the timolol dose according to heart rate and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Timolol?
MediHelp rates the interaction as moderate. Dronedarone and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP2D6 and also has beta-blocking and negative chronotropic properties. Combined with timolol it may raise beta-blocker exposure and increase the risk of bradycardia, AV block and hypotension.
How serious is the interaction between Dronedarone and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low beta-blocker dose and obtain an ECG to check for bradycardia or conduction delay. Adjust the timolol dose according to heart rate and blood pressure.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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