Drug interactions
Dronedarone + Vandetanib
Severity: Contraindicated
Dronedarone and Vandetanib: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and vandetanib carries a boxed warning for QT prolongation and torsades de pointes. Combined use markedly increases the risk of fatal arrhythmia.
What this interaction means in plain words
Dronedarone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Vandetanib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Do not combine; select an alternative to dronedarone. Vandetanib labeling advises against concurrent QT-prolonging drugs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Dronedarone with Vandetanib?
MediHelp rates the interaction as contraindicated. Dronedarone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and vandetanib carries a boxed warning for QT prolongation and torsades de pointes. Combined use markedly increases the risk of fatal arrhythmia.
How serious is the interaction between Dronedarone and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select an alternative to dronedarone. Vandetanib labeling advises against concurrent QT-prolonging drugs.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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