Drug interactions
Dronedarone + Vincristine
Severity: Moderate
Dronedarone and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase vincristine exposure through P-glycoprotein inhibition. Greater exposure could worsen peripheral neuropathy, constipation and other neurotoxicity.
What this interaction means in plain words
Dronedarone and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Vincristine belongs to Oncology.
Why it happens
Dronedarone inhibits P-glycoprotein, reducing vincristine efflux and elimination.
What to do
Monitor for neurotoxicity such as neuropathy and constipation. Reduce the vincristine dose or choose an alternative antiarrhythmic if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Dronedarone with Vincristine?
MediHelp rates the interaction as moderate. Dronedarone and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may increase vincristine exposure through P-glycoprotein inhibition. Greater exposure could worsen peripheral neuropathy, constipation and other neurotoxicity.
How serious is the interaction between Dronedarone and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurotoxicity such as neuropathy and constipation. Reduce the vincristine dose or choose an alternative antiarrhythmic if toxicity appears.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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