Drug interactions
Dronedarone + Vinorelbine
Severity: Moderate
Dronedarone and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinorelbine is metabolized by CYP3A4, so inhibition by dronedarone may increase vinorelbine exposure. This could worsen neutropenia and neurotoxicity, and dronedarone also inhibits P-glycoprotein.
What this interaction means in plain words
Dronedarone and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Vinorelbine belongs to Oncology.
Why it happens
Dronedarone inhibits CYP3A4 and P-glycoprotein, reducing vinorelbine clearance.
What to do
Monitor neutrophil counts and signs of neuropathy or constipation. Reduce the vinorelbine dose if myelosuppression is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Vinorelbine
Frequently asked questions
Can I take Dronedarone with Vinorelbine?
MediHelp rates the interaction as moderate. Dronedarone and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vinorelbine is metabolized by CYP3A4, so inhibition by dronedarone may increase vinorelbine exposure. This could worsen neutropenia and neurotoxicity, and dronedarone also inhibits P-glycoprotein.
How serious is the interaction between Dronedarone and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of neuropathy or constipation. Reduce the vinorelbine dose if myelosuppression is excessive.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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