Drug interactions
Droperidol + Goserelin
Severity: Major
Droperidol and Goserelin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol carries a boxed warning for QT prolongation and torsades de pointes, and goserelin may add to the risk. Combining them increases the likelihood of a serious ventricular arrhythmia.
What this interaction means in plain words
Droperidol and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation, with droperidol blocking cardiac potassium channels.
What to do
Avoid if possible, or use only with a baseline ECG, continuous monitoring and correction of electrolytes. Choose a non-QT-prolonging antiemetic or sedative where feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Goserelin
Frequently asked questions
Can I take Droperidol with Goserelin?
MediHelp rates the interaction as major. Droperidol and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Droperidol carries a boxed warning for QT prolongation and torsades de pointes, and goserelin may add to the risk. Combining them increases the likelihood of a serious ventricular arrhythmia.
How serious is the interaction between Droperidol and Goserelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or use only with a baseline ECG, continuous monitoring and correction of electrolytes. Choose a non-QT-prolonging antiemetic or sedative where feasible.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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