Drug interactions
Droperidol + Modafinil
Severity: Moderate
Droperidol and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol is sedating and prolongs the QT interval, while modafinil promotes wakefulness and can raise heart rate. Modafinil does not counteract droperidol arrhythmia risk, and sedation effects are unpredictable.
What this interaction means in plain words
Droperidol and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing effects on arousal; additive cardiac stimulation may compound droperidol QT-related risk.
What to do
Obtain an ECG before and monitor after droperidol and correct potassium and magnesium. Monitor sedation and avoid relying on modafinil to offset it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Droperidol and Modafinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Modafinil
Frequently asked questions
Can I take Droperidol with Modafinil?
MediHelp rates the interaction as moderate. Droperidol and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol is sedating and prolongs the QT interval, while modafinil promotes wakefulness and can raise heart rate. Modafinil does not counteract droperidol arrhythmia risk, and sedation effects are unpredictable.
How serious is the interaction between Droperidol and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before and monitor after droperidol and correct potassium and magnesium. Monitor sedation and avoid relying on modafinil to offset it.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
