Drug interactions
Drospirenone + Furosemide
Severity: Moderate
Drospirenone and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise potassium, whereas furosemide lowers it. The net effect on potassium is variable, and volume depletion or renal impairment increases risk of hyperkalemia.
What this interaction means in plain words
Drospirenone and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Furosemide belongs to Cardiovascular.
Why it happens
Drospirenone blocks aldosterone receptors, reducing potassium excretion, while furosemide increases renal potassium loss.
What to do
Check serum potassium during early combined use and periodically thereafter, particularly in renal impairment. Adjust therapy if potassium is abnormal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Furosemide?
MediHelp rates the interaction as moderate. Drospirenone and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise potassium, whereas furosemide lowers it. The net effect on potassium is variable, and volume depletion or renal impairment increases risk of hyperkalemia.
How serious is the interaction between Drospirenone and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during early combined use and periodically thereafter, particularly in renal impairment. Adjust therapy if potassium is abnormal.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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