Drug interactions
Drospirenone + Hydrochlorothiazide-lisinopril
Severity: Moderate
Drospirenone and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and can raise serum potassium, and lisinopril adds to this effect. Hydrochlorothiazide offsets it partly, but hyperkalemia remains possible, especially with renal impairment.
What this interaction means in plain words
Drospirenone and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Drospirenone antagonizes aldosterone and ACE inhibition lowers aldosterone, both reducing potassium excretion.
What to do
Check serum potassium during the first cycle of treatment and periodically thereafter; choose another contraceptive if potassium is elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Drospirenone and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has anti-mineralocorticoid activity and can raise serum potassium, and lisinopril adds to this effect. Hydrochlorothiazide offsets it partly, but hyperkalemia remains possible, especially with renal impairment.
How serious is the interaction between Drospirenone and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of treatment and periodically thereafter; choose another contraceptive if potassium is elevated.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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