Drug interactions
Drospirenone + Imidapril
Severity: Moderate
Drospirenone and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and ACE inhibitors reduce aldosterone, so both can raise serum potassium. Hyperkalemia risk is higher in renal impairment, diabetes or with other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Imidapril belongs to Cardiovascular.
Why it happens
Additive potassium retention from aldosterone antagonism by drospirenone and reduced aldosterone production with ACE inhibition.
What to do
Check serum potassium during the first cycle of combined use and periodically thereafter, especially in patients with renal impairment. Choose a different contraceptive if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Drospirenone with Imidapril?
MediHelp rates the interaction as moderate. Drospirenone and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and ACE inhibitors reduce aldosterone, so both can raise serum potassium. Hyperkalemia risk is higher in renal impairment, diabetes or with other potassium-raising drugs.
How serious is the interaction between Drospirenone and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of combined use and periodically thereafter, especially in patients with renal impairment. Choose a different contraceptive if hyperkalemia develops.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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