Drug interactions
Drospirenone + Itraconazole
Severity: Moderate
Drospirenone and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole, a strong CYP3A4 inhibitor, can raise drospirenone exposure, though drospirenone is mainly cleared by non-CYP pathways, so the increase is modest. Drospirenone has anti-mineralocorticoid activity that can raise potassium, which is the main concern with higher exposure.
What this interaction means in plain words
Drospirenone and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4, which has a minor role in drospirenone metabolism, modestly increasing its exposure.
What to do
Monitor serum potassium in the first treatment cycle, especially in patients with renal impairment or on other potassium-raising drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Itraconazole?
MediHelp rates the interaction as moderate. Drospirenone and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole, a strong CYP3A4 inhibitor, can raise drospirenone exposure, though drospirenone is mainly cleared by non-CYP pathways, so the increase is modest. Drospirenone has anti-mineralocorticoid activity that can raise potassium, which is the main concern with higher exposure.
How serious is the interaction between Drospirenone and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in the first treatment cycle, especially in patients with renal impairment or on other potassium-raising drugs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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