Drug interactions
Drospirenone + Labetalol
Severity: Minor
Drospirenone and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium. Beta-blockers can modestly raise potassium by impairing cellular uptake, so hyperkalemia is possible, mainly in patients with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Labetalol belongs to Cardiovascular.
Why it happens
Additive potassium elevation from aldosterone antagonism and beta-blocker inhibition of cellular potassium uptake.
What to do
Check serum potassium in high-risk patients, such as those with renal impairment or on other potassium-raising drugs, during the first cycle.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Labetalol?
MediHelp rates the interaction as minor. Drospirenone and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has antimineralocorticoid activity and can raise serum potassium. Beta-blockers can modestly raise potassium by impairing cellular uptake, so hyperkalemia is possible, mainly in patients with renal impairment or other potassium-raising drugs.
How serious is the interaction between Drospirenone and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in high-risk patients, such as those with renal impairment or on other potassium-raising drugs, during the first cycle.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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