Drug interactions
Drospirenone + Lornoxicam
Severity: Moderate
Drospirenone and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity that can raise serum potassium, and NSAIDs such as lornoxicam can reduce renal potassium excretion. The combination may increase hyperkalemia risk, particularly with renal impairment.
What this interaction means in plain words
Drospirenone and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive hyperkalemic effects from aldosterone antagonism by drospirenone and NSAID-induced reduction in renal potassium excretion.
What to do
Monitor serum potassium in the first treatment cycle when used with chronic NSAID therapy, and avoid in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Drospirenone and Lornoxicam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Drospirenone
Other interactions of Lornoxicam
Frequently asked questions
Can I take Drospirenone with Lornoxicam?
MediHelp rates the interaction as moderate. Drospirenone and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity that can raise serum potassium, and NSAIDs such as lornoxicam can reduce renal potassium excretion. The combination may increase hyperkalemia risk, particularly with renal impairment.
How serious is the interaction between Drospirenone and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in the first treatment cycle when used with chronic NSAID therapy, and avoid in patients with renal impairment.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
