Drug interactions
Drospirenone + Losartan
Severity: Moderate
Drospirenone and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is a progestin with antimineralocorticoid activity that can raise serum potassium, and losartan also reduces potassium excretion. Together they may cause hyperkalemia, particularly in patients with renal impairment.
What this interaction means in plain words
Drospirenone and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Losartan belongs to Cardiovascular.
Why it happens
Additive potassium retention through angiotensin receptor blockade and drospirenone's aldosterone antagonism.
What to do
Check serum potassium during the first cycle of treatment and periodically thereafter. Avoid the combination in patients with renal impairment or other hyperkalemia risks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Losartan?
MediHelp rates the interaction as moderate. Drospirenone and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone is a progestin with antimineralocorticoid activity that can raise serum potassium, and losartan also reduces potassium excretion. Together they may cause hyperkalemia, particularly in patients with renal impairment.
How serious is the interaction between Drospirenone and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of treatment and periodically thereafter. Avoid the combination in patients with renal impairment or other hyperkalemia risks.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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