Drug interactions
Drospirenone + Mefenamic acid
Severity: Moderate
Drospirenone and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs may add to this by reducing renal potassium excretion. Hyperkalemia is mainly a concern in renal impairment or with other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Additive hyperkalemia from aldosterone antagonism and NSAID-induced suppression of renin and renal prostaglandins.
What to do
Check serum potassium in the first treatment cycle in at-risk patients and avoid prolonged daily NSAID use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Mefenamic acid?
MediHelp rates the interaction as moderate. Drospirenone and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs may add to this by reducing renal potassium excretion. Hyperkalemia is mainly a concern in renal impairment or with other potassium-raising drugs.
How serious is the interaction between Drospirenone and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first treatment cycle in at-risk patients and avoid prolonged daily NSAID use.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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