Drug interactions
Drospirenone + Midazolam
Severity: Minor
Drospirenone and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is not a clinically relevant CYP3A4 inhibitor, so a meaningful increase in midazolam exposure is unlikely. Any effect on sedation is expected to be minimal.
What this interaction means in plain words
Drospirenone and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Midazolam belongs to Central Nervous System.
Why it happens
Weak in vitro CYP3A4 inhibition by drospirenone without established clinical significance.
What to do
No adjustment needed; monitor sedation as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Midazolam?
MediHelp rates the interaction as minor. Drospirenone and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone is not a clinically relevant CYP3A4 inhibitor, so a meaningful increase in midazolam exposure is unlikely. Any effect on sedation is expected to be minimal.
How serious is the interaction between Drospirenone and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; monitor sedation as usual.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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