Drug interactions
Drospirenone + Nabumetone
Severity: Moderate
Drospirenone and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs may add to this effect through renal mechanisms. Hyperkalemia is more likely in patients with renal impairment or on other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Nabumetone belongs to Musculoskeletal.
Why it happens
Aldosterone antagonism by drospirenone plus NSAID-induced suppression of renin-aldosterone and reduced renal potassium excretion.
What to do
In patients at risk, check serum potassium during the first cycle of combined use; otherwise no routine action is needed for short-term NSAID use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Nabumetone?
MediHelp rates the interaction as moderate. Drospirenone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs may add to this effect through renal mechanisms. Hyperkalemia is more likely in patients with renal impairment or on other potassium-raising drugs.
How serious is the interaction between Drospirenone and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients at risk, check serum potassium during the first cycle of combined use; otherwise no routine action is needed for short-term NSAID use.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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