Drug interactions
Drospirenone + Piroxicam
Severity: Moderate
Drospirenone and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and can raise potassium, and NSAIDs may add to this effect. In most healthy women the risk is small, but it is higher with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Piroxicam belongs to Musculoskeletal.
Why it happens
Additive potassium retention from drospirenone aldosterone antagonism and NSAID-related suppression of renin-aldosterone and renal perfusion.
What to do
In patients at risk, check serum potassium during the first treatment cycle with long-term NSAID use. Avoid in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Piroxicam?
MediHelp rates the interaction as moderate. Drospirenone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has anti-mineralocorticoid activity and can raise potassium, and NSAIDs may add to this effect. In most healthy women the risk is small, but it is higher with renal impairment or other potassium-raising drugs.
How serious is the interaction between Drospirenone and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients at risk, check serum potassium during the first treatment cycle with long-term NSAID use. Avoid in renal impairment.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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