Drug interactions
Drospirenone + Potassium iodide
Severity: Moderate
Drospirenone and Potassium iodide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide supplies a potassium load and drospirenone reduces renal potassium excretion. Hyperkalemia is possible, particularly with prolonged use or kidney impairment.
What this interaction means in plain words
Drospirenone and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Potassium iodide belongs to Endocrine.
Why it happens
Additive effect: potassium load plus drospirenone anti-mineralocorticoid activity.
What to do
Monitor serum potassium if potassium iodide is used for more than short periods.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Drospirenone with Potassium iodide?
MediHelp rates the interaction as moderate. Drospirenone and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium iodide supplies a potassium load and drospirenone reduces renal potassium excretion. Hyperkalemia is possible, particularly with prolonged use or kidney impairment.
How serious is the interaction between Drospirenone and Potassium iodide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium if potassium iodide is used for more than short periods.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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