Drug interactions
Drospirenone + Succinylcholine
Severity: Minor
Drospirenone and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine releases potassium from muscle, and drospirenone has antimineralocorticoid activity that can raise serum potassium. Together they may increase hyperkalemia risk, mainly with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Succinylcholine belongs to Musculoskeletal.
Why it happens
Additive hyperkalemia from depolarization-induced potassium efflux plus aldosterone antagonism reducing renal potassium excretion.
What to do
Check serum potassium before anesthesia in patients with renal impairment or other risk factors. Monitor ECG and potassium perioperatively when risk is present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Succinylcholine
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Succinylcholine?
MediHelp rates the interaction as minor. Drospirenone and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Succinylcholine releases potassium from muscle, and drospirenone has antimineralocorticoid activity that can raise serum potassium. Together they may increase hyperkalemia risk, mainly with renal impairment or other potassium-raising drugs.
How serious is the interaction between Drospirenone and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before anesthesia in patients with renal impairment or other risk factors. Monitor ECG and potassium perioperatively when risk is present.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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