Drug interactions
Drospirenone + Torsemide
Severity: Moderate
Drospirenone and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity that retains potassium, partly offsetting the potassium loss caused by torsemide. The net effect on potassium is variable, and hyperkalemia is possible in patients with renal impairment.
What this interaction means in plain words
Drospirenone and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Torsemide belongs to Cardiovascular.
Why it happens
Opposing effects on potassium: loop diuretic kaliuresis versus aldosterone antagonism by drospirenone.
What to do
Check serum potassium during the first weeks of combined use, especially with renal impairment or other potassium-raising drugs. Choose a different contraceptive if hyperkalemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Torsemide?
MediHelp rates the interaction as moderate. Drospirenone and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity that retains potassium, partly offsetting the potassium loss caused by torsemide. The net effect on potassium is variable, and hyperkalemia is possible in patients with renal impairment.
How serious is the interaction between Drospirenone and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first weeks of combined use, especially with renal impairment or other potassium-raising drugs. Choose a different contraceptive if hyperkalemia occurs.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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