Drug interactions
Drospirenone + Voriconazole
Severity: Minor
Drospirenone and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is not a recognized inhibitor of voriconazole metabolism. In the opposite direction, voriconazole may increase drospirenone exposure and its potassium-raising effect, which is of limited significance in healthy users.
What this interaction means in plain words
Drospirenone and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 and may modestly raise drospirenone levels.
What to do
Monitor serum potassium in patients with renal impairment or on other potassium-raising drugs. No routine change is needed in healthy users.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Voriconazole?
MediHelp rates the interaction as minor. Drospirenone and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone is not a recognized inhibitor of voriconazole metabolism. In the opposite direction, voriconazole may increase drospirenone exposure and its potassium-raising effect, which is of limited significance in healthy users.
How serious is the interaction between Drospirenone and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with renal impairment or on other potassium-raising drugs. No routine change is needed in healthy users.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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