Drug interactions
Droxidopa + Sumatriptan
Severity: Moderate
Droxidopa and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droxidopa is converted to norepinephrine and can cause supine hypertension, while sumatriptan can raise blood pressure through vasoconstriction. Together they may increase the risk of excessive blood pressure elevation.
What this interaction means in plain words
Droxidopa and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Droxidopa belongs to Cardiovascular; Sumatriptan belongs to Central Nervous System.
Why it happens
Additive pressor effects from norepinephrine formation and triptan-mediated vasoconstriction.
What to do
Monitor blood pressure, including in the supine position, when starting or adjusting either drug. Reduce or stop droxidopa if supine hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Droxidopa and Sumatriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Other interactions of Droxidopa
- Droxidopa + Lisdexamfetamine Major
- Droxidopa + Methamphetamine Major
- Droxidopa + Pseudoephedrine Major
- Adrenaline-articaine + Droxidopa Moderate
- Almotriptan + Droxidopa Moderate
- Caffeine + Droxidopa Moderate
Frequently asked questions
Can I take Droxidopa with Sumatriptan?
MediHelp rates the interaction as moderate. Droxidopa and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droxidopa is converted to norepinephrine and can cause supine hypertension, while sumatriptan can raise blood pressure through vasoconstriction. Together they may increase the risk of excessive blood pressure elevation.
How serious is the interaction between Droxidopa and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including in the supine position, when starting or adjusting either drug. Reduce or stop droxidopa if supine hypertension develops.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
