Drug interactions
Dulaglutide + Levothyroxine
Severity: Minor
Dulaglutide and Levothyroxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide slows gastric emptying, which could alter the absorption of oral levothyroxine. The clinical effect is usually small, but levothyroxine has a narrow therapeutic range.
What this interaction means in plain words
Dulaglutide and Levothyroxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dulaglutide belongs to Endocrine; Levothyroxine belongs to Endocrine.
Why it happens
Delayed gastric emptying from GLP-1 receptor agonism may change the rate and extent of levothyroxine absorption.
What to do
No routine dose change is needed. Check TSH after starting dulaglutide or if the patient develops symptoms of thyroid dysfunction.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levothyroxine
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Levothyroxine?
MediHelp rates the interaction as minor. Dulaglutide and Levothyroxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dulaglutide slows gastric emptying, which could alter the absorption of oral levothyroxine. The clinical effect is usually small, but levothyroxine has a narrow therapeutic range.
How serious is the interaction between Dulaglutide and Levothyroxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Check TSH after starting dulaglutide or if the patient develops symptoms of thyroid dysfunction.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
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