Drug interactions
Dulaglutide + Saxagliptin-metformin
Severity: Moderate
Dulaglutide and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide combined with saxagliptin and metformin gives additive glucose lowering, but combining a GLP-1 agonist with a DPP-4 inhibitor offers little added benefit. Gastrointestinal effects may be more pronounced.
What this interaction means in plain words
Dulaglutide and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Overlapping incretin pathway: GLP-1 receptor agonism plus DPP-4 inhibition.
What to do
Generally avoid combining a DPP-4 inhibitor with a GLP-1 agonist; stop saxagliptin when dulaglutide is started. Monitor glucose and GI tolerance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Dulaglutide and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide combined with saxagliptin and metformin gives additive glucose lowering, but combining a GLP-1 agonist with a DPP-4 inhibitor offers little added benefit. Gastrointestinal effects may be more pronounced.
How serious is the interaction between Dulaglutide and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Generally avoid combining a DPP-4 inhibitor with a GLP-1 agonist; stop saxagliptin when dulaglutide is started. Monitor glucose and GI tolerance.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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