Drug interactions
Dulaglutide + Tolazamide
Severity: Moderate
Dulaglutide and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide increases glucose-dependent insulin secretion, and combined with a sulfonylurea it raises the risk of hypoglycemia. Sulfonylurea dose reduction is often needed.
What this interaction means in plain words
Dulaglutide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive insulinotropic effects of GLP-1 receptor agonism and sulfonylurea-mediated insulin release.
What to do
Consider lowering the tolazamide dose when starting dulaglutide and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Tolazamide?
MediHelp rates the interaction as moderate. Dulaglutide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide increases glucose-dependent insulin secretion, and combined with a sulfonylurea it raises the risk of hypoglycemia. Sulfonylurea dose reduction is often needed.
How serious is the interaction between Dulaglutide and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the tolazamide dose when starting dulaglutide and monitor blood glucose.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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