Drug interactions
Duloxetine + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Duloxetine and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP2D6 and CYP3A4, and duloxetine is metabolized by CYP2D6 and CYP1A2. Duloxetine concentrations may rise, increasing nausea, dizziness, blood pressure elevation and other adverse effects.
What this interaction means in plain words
Duloxetine and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibition of CYP2D6-mediated duloxetine metabolism.
What to do
Monitor for duloxetine adverse effects and consider a lower dose if tolerability problems occur. Titrate duloxetine slowly when starting it in patients on this regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Duloxetine and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP2D6 and CYP3A4, and duloxetine is metabolized by CYP2D6 and CYP1A2. Duloxetine concentrations may rise, increasing nausea, dizziness, blood pressure elevation and other adverse effects.
How serious is the interaction between Duloxetine and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects and consider a lower dose if tolerability problems occur. Titrate duloxetine slowly when starting it in patients on this regimen.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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