Drug interactions
Duloxetine + Ethinylestradiol
Severity: Minor
Duloxetine and Ethinylestradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol is a weak CYP1A2 inhibitor and may modestly increase duloxetine exposure. The effect is generally small and rarely clinically relevant.
What this interaction means in plain words
Duloxetine and Ethinylestradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP1A2-mediated duloxetine metabolism.
What to do
No dose change is usually needed. Be aware of increased duloxetine adverse effects if symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Ethinylestradiol?
MediHelp rates the interaction as minor. Duloxetine and Ethinylestradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinylestradiol is a weak CYP1A2 inhibitor and may modestly increase duloxetine exposure. The effect is generally small and rarely clinically relevant.
How serious is the interaction between Duloxetine and Ethinylestradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Be aware of increased duloxetine adverse effects if symptoms emerge.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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