Drug interactions
Duloxetine + Fenbufen
Severity: Moderate
Duloxetine and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine and NSAIDs such as fenbufen each raise the risk of bleeding, and together the risk of gastrointestinal hemorrhage is greater than with either alone. The risk is higher in older patients and those with ulcer history or anticoagulant use.
What this interaction means in plain words
Duloxetine and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duloxetine impairs platelet serotonin uptake and aggregation while the NSAID inhibits platelet function and damages gastric mucosa.
What to do
Monitor for signs of GI bleeding and use the lowest effective NSAID dose for the shortest time. Consider gastroprotection with a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Fenbufen?
MediHelp rates the interaction as moderate. Duloxetine and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine and NSAIDs such as fenbufen each raise the risk of bleeding, and together the risk of gastrointestinal hemorrhage is greater than with either alone. The risk is higher in older patients and those with ulcer history or anticoagulant use.
How serious is the interaction between Duloxetine and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and use the lowest effective NSAID dose for the shortest time. Consider gastroprotection with a proton pump inhibitor in high-risk patients.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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