Drug interactions
Duloxetine + Fexinidazole
Severity: Moderate
Duloxetine and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its active metabolites may inhibit CYP1A2, a major pathway for duloxetine clearance. Duloxetine levels could rise, increasing adverse effects. Fexinidazole is given as a short course for sleeping sickness, so exposure is time-limited.
What this interaction means in plain words
Duloxetine and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP1A2 inhibition by fexinidazole reduces duloxetine metabolism.
What to do
Monitor for duloxetine toxicity such as nausea, dizziness and serotonergic symptoms during the fexinidazole course. Consider a temporary duloxetine dose reduction if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Fexinidazole?
MediHelp rates the interaction as moderate. Duloxetine and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its active metabolites may inhibit CYP1A2, a major pathway for duloxetine clearance. Duloxetine levels could rise, increasing adverse effects. Fexinidazole is given as a short course for sleeping sickness, so exposure is time-limited.
How serious is the interaction between Duloxetine and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine toxicity such as nausea, dizziness and serotonergic symptoms during the fexinidazole course. Consider a temporary duloxetine dose reduction if adverse effects develop.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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