Drug interactions
Duloxetine + Isoniazid
Severity: Moderate
Duloxetine and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak MAO inhibiting activity, so combined use with duloxetine carries a theoretical risk of serotonin toxicity. Clinical reports are scarce.
What this interaction means in plain words
Duloxetine and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Additive serotonergic effect from weak MAO inhibition and serotonin-noradrenaline reuptake inhibition.
What to do
Monitor for agitation, tremor, clonus, hyperthermia and diarrhea, especially after dose changes. Stop one agent if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Isoniazid?
MediHelp rates the interaction as moderate. Duloxetine and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid has weak MAO inhibiting activity, so combined use with duloxetine carries a theoretical risk of serotonin toxicity. Clinical reports are scarce.
How serious is the interaction between Duloxetine and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, hyperthermia and diarrhea, especially after dose changes. Stop one agent if serotonin syndrome is suspected.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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