Drug interactions
Duloxetine + Ketorolac intranasal
Severity: Moderate
Duloxetine and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is absorbed systemically after intranasal use, and it is a potent NSAID with a significant bleeding risk. Combined with duloxetine's effect on platelets, the chance of gastrointestinal and other bleeding increases.
What this interaction means in plain words
Duloxetine and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duloxetine reduces platelet serotonin uptake while ketorolac inhibits platelet cyclooxygenase and injures gastric mucosa.
What to do
Limit ketorolac to the shortest course permitted and monitor for GI bleeding signs. Consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Duloxetine and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is absorbed systemically after intranasal use, and it is a potent NSAID with a significant bleeding risk. Combined with duloxetine's effect on platelets, the chance of gastrointestinal and other bleeding increases.
How serious is the interaction between Duloxetine and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest course permitted and monitor for GI bleeding signs. Consider gastroprotection in high-risk patients.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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