Drug interactions
Duloxetine + Lsd
Severity: Moderate
Duloxetine and Lsd: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a potent serotonin receptor agonist and duloxetine increases synaptic serotonin. Serotonin reuptake inhibitors generally blunt LSD's effects, but the combination may still cause serotonergic toxicity, and the interaction is poorly characterized.
What this interaction means in plain words
Duloxetine and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Overlapping serotonergic activity through 5-HT receptor agonism and reuptake inhibition.
What to do
Advise against use of LSD with duloxetine. If exposure occurs, monitor for signs of serotonin syndrome and manage supportively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Lsd?
MediHelp rates the interaction as moderate. Duloxetine and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD is a potent serotonin receptor agonist and duloxetine increases synaptic serotonin. Serotonin reuptake inhibitors generally blunt LSD's effects, but the combination may still cause serotonergic toxicity, and the interaction is poorly characterized.
How serious is the interaction between Duloxetine and Lsd?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against use of LSD with duloxetine. If exposure occurs, monitor for signs of serotonin syndrome and manage supportively.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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