Drug interactions
Duloxetine + Lumefantrine
Severity: Moderate
Duloxetine and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6 and may modestly raise duloxetine exposure, increasing adverse effects such as nausea, dizziness and blood pressure rise. Both drugs also have some potential for QT effects, though this is more established for lumefantrine. The interaction is usually manageable.
What this interaction means in plain words
Duloxetine and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated metabolism of duloxetine by lumefantrine.
What to do
Monitor for duloxetine adverse effects and consider a baseline ECG if other QT-prolonging risks are present. Dose reduction is rarely needed for a short antimalarial course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Lumefantrine?
MediHelp rates the interaction as moderate. Duloxetine and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine inhibits CYP2D6 and may modestly raise duloxetine exposure, increasing adverse effects such as nausea, dizziness and blood pressure rise. Both drugs also have some potential for QT effects, though this is more established for lumefantrine. The interaction is usually manageable.
How serious is the interaction between Duloxetine and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects and consider a baseline ECG if other QT-prolonging risks are present. Dose reduction is rarely needed for a short antimalarial course.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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