Drug interactions
Duloxetine + Marijuana
Severity: Minor
Duloxetine and Marijuana: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis products, especially cannabidiol, can inhibit CYP2D6 and CYP1A2 in vitro. Duloxetine exposure might rise, and additive sedation, dizziness and impaired cognition are also possible.
What this interaction means in plain words
Duloxetine and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cannabinoids may inhibit CYP2D6 and CYP1A2 and add CNS depressant effects.
What to do
Counsel patients about additive drowsiness and monitor for duloxetine adverse effects when cannabis use is regular.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Marijuana?
MediHelp rates the interaction as minor. Duloxetine and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabis products, especially cannabidiol, can inhibit CYP2D6 and CYP1A2 in vitro. Duloxetine exposure might rise, and additive sedation, dizziness and impaired cognition are also possible.
How serious is the interaction between Duloxetine and Marijuana?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and monitor for duloxetine adverse effects when cannabis use is regular.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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