Drug interactions
Duloxetine + Meclofenamate
Severity: Moderate
Duloxetine and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine combined with an NSAID such as meclofenamate increases the risk of gastrointestinal and other bleeding compared with either drug alone. The risk rises with age, prior ulcers and concurrent anticoagulants.
What this interaction means in plain words
Duloxetine and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Impaired platelet aggregation from serotonin reuptake inhibition plus NSAID cyclooxygenase inhibition and mucosal injury.
What to do
Monitor for GI bleeding and use the lowest effective NSAID dose for the shortest time. Consider a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Meclofenamate?
MediHelp rates the interaction as moderate. Duloxetine and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine combined with an NSAID such as meclofenamate increases the risk of gastrointestinal and other bleeding compared with either drug alone. The risk rises with age, prior ulcers and concurrent anticoagulants.
How serious is the interaction between Duloxetine and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and use the lowest effective NSAID dose for the shortest time. Consider a proton pump inhibitor in high-risk patients.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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