Drug interactions
Duloxetine + Metoclopramide intranasal
Severity: Moderate
Duloxetine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide has been associated with serotonin syndrome and extrapyramidal reactions, and combining it with serotonergic antidepressants may increase these risks. Duloxetine inhibits CYP2D6, which metabolizes metoclopramide, so exposure to metoclopramide may rise and worsen movement-related adverse effects.
What this interaction means in plain words
Duloxetine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition by duloxetine raising metoclopramide levels, plus additive serotonergic and dopamine-antagonist effects.
What to do
Monitor for extrapyramidal symptoms and serotonin toxicity, and use a lower metoclopramide dose if a CYP2D6 inhibitor is needed. Consider another antiemetic if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Duloxetine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide has been associated with serotonin syndrome and extrapyramidal reactions, and combining it with serotonergic antidepressants may increase these risks. Duloxetine inhibits CYP2D6, which metabolizes metoclopramide, so exposure to metoclopramide may rise and worsen movement-related adverse effects.
How serious is the interaction between Duloxetine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and serotonin toxicity, and use a lower metoclopramide dose if a CYP2D6 inhibitor is needed. Consider another antiemetic if symptoms appear.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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