Drug interactions
Duloxetine + Midazolam intranasal
Severity: Moderate
Duloxetine and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a benzodiazepine that depresses the CNS and respiration, and duloxetine may add sedation and dizziness. The combination may deepen sedation, although the respiratory risk is mainly relevant with opioids and other strong depressants.
What this interaction means in plain words
Duloxetine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor sedation level and respiratory status after midazolam administration. Reduce the midazolam dose when other CNS-active drugs are on board.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Midazolam intranasal?
MediHelp rates the interaction as moderate. Duloxetine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam is a benzodiazepine that depresses the CNS and respiration, and duloxetine may add sedation and dizziness. The combination may deepen sedation, although the respiratory risk is mainly relevant with opioids and other strong depressants.
How serious is the interaction between Duloxetine and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status after midazolam administration. Reduce the midazolam dose when other CNS-active drugs are on board.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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