Drug interactions
Duloxetine + Olanzapine / samidorphan
Severity: Moderate
Duloxetine and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine causes sedation and orthostatic hypotension, and duloxetine can also cause dizziness and blood pressure changes. Together these effects may be additive. Duloxetine, a CYP2D6 inhibitor, may modestly raise olanzapine exposure, though CYP1A2 is its main route.
What this interaction means in plain words
Duloxetine and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and hypotensive effects, with possible minor pharmacokinetic interaction.
What to do
Monitor for sedation, orthostatic hypotension and falls, particularly in older patients. Adjust doses if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Duloxetine and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine causes sedation and orthostatic hypotension, and duloxetine can also cause dizziness and blood pressure changes. Together these effects may be additive. Duloxetine, a CYP2D6 inhibitor, may modestly raise olanzapine exposure, though CYP1A2 is its main route.
How serious is the interaction between Duloxetine and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and falls, particularly in older patients. Adjust doses if symptoms develop.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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