Drug interactions
Duloxetine + Parecoxib
Severity: Moderate
Duloxetine and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, a COX-2 inhibitor that carries lower GI risk than non-selective NSAIDs but still adds to bleeding risk when combined with duloxetine. Pharmacokinetic inhibition of CYP2D6 by the coxib is not clinically established.
What this interaction means in plain words
Duloxetine and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effect on bleeding through impaired platelet serotonin uptake and COX-2 inhibition-related mucosal effects.
What to do
Monitor for bleeding signs, especially in patients with GI risk factors, and keep parecoxib use short.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Parecoxib?
MediHelp rates the interaction as moderate. Duloxetine and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib is converted to valdecoxib, a COX-2 inhibitor that carries lower GI risk than non-selective NSAIDs but still adds to bleeding risk when combined with duloxetine. Pharmacokinetic inhibition of CYP2D6 by the coxib is not clinically established.
How serious is the interaction between Duloxetine and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs, especially in patients with GI risk factors, and keep parecoxib use short.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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