Drug interactions
Duloxetine + Peginterferon alfa 2a
Severity: Moderate
Duloxetine and Peginterferon alfa 2a: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa-2a inhibits CYP1A2 and may raise duloxetine concentrations, which could increase adverse effects such as nausea, sedation, blood pressure elevation and serotonergic effects. Interferon-related depression may also complicate the use of an antidepressant.
What this interaction means in plain words
Duloxetine and Peginterferon alfa 2a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Peginterferon alfa 2a belongs to Anti Virals.
Why it happens
Peginterferon alfa-2a inhibits CYP1A2, the main enzyme metabolizing duloxetine, which reduces its clearance.
What to do
Monitor for duloxetine adverse effects and consider a lower duloxetine dose if they occur. Monitor mood and hepatic function during combined therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Peginterferon alfa 2a
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Peginterferon alfa 2a?
MediHelp rates the interaction as moderate. Duloxetine and Peginterferon alfa 2a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Peginterferon alfa-2a inhibits CYP1A2 and may raise duloxetine concentrations, which could increase adverse effects such as nausea, sedation, blood pressure elevation and serotonergic effects. Interferon-related depression may also complicate the use of an antidepressant.
How serious is the interaction between Duloxetine and Peginterferon alfa 2a?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects and consider a lower duloxetine dose if they occur. Monitor mood and hepatic function during combined therapy.
What other medicines interact with Peginterferon alfa 2a?
MediHelp also lists interactions of Peginterferon alfa 2a with, for example, Clozapine, Deferiprone, Hydroxycarbamide. The full list is on the Peginterferon alfa 2a page.
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