Drug interactions
Duloxetine + Pentobarbital
Severity: Moderate
Duloxetine and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces hepatic enzymes including CYP1A2 and may lower duloxetine concentrations and reduce antidepressant effect. Both drugs also cause CNS depression, so sedation and psychomotor impairment may be additive.
What this interaction means in plain words
Duloxetine and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme induction by pentobarbital increasing duloxetine clearance, plus additive CNS depression.
What to do
Monitor for loss of duloxetine efficacy and excess sedation, and adjust the duloxetine dose based on response. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Pentobarbital?
MediHelp rates the interaction as moderate. Duloxetine and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces hepatic enzymes including CYP1A2 and may lower duloxetine concentrations and reduce antidepressant effect. Both drugs also cause CNS depression, so sedation and psychomotor impairment may be additive.
How serious is the interaction between Duloxetine and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of duloxetine efficacy and excess sedation, and adjust the duloxetine dose based on response. Avoid alcohol and other sedatives.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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