Drug interactions
Duloxetine + Promazine
Severity: Moderate
Duloxetine and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine inhibits CYP2D6, which contributes to the metabolism of phenothiazines such as promazine. Exposure to promazine may rise, increasing sedation, hypotension and QT prolongation risk.
What this interaction means in plain words
Duloxetine and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duloxetine inhibits CYP2D6, reducing promazine clearance; additive QT and CNS effects are also possible.
What to do
Monitor for sedation, orthostatic hypotension and QT prolongation, and lower the promazine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Promazine?
MediHelp rates the interaction as moderate. Duloxetine and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine inhibits CYP2D6, which contributes to the metabolism of phenothiazines such as promazine. Exposure to promazine may rise, increasing sedation, hypotension and QT prolongation risk.
How serious is the interaction between Duloxetine and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and QT prolongation, and lower the promazine dose if adverse effects appear.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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