Drug interactions
Duloxetine + Quinacrine
Severity: Moderate
Duloxetine and Quinacrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6, which participates in duloxetine metabolism. Duloxetine levels could therefore increase, raising the risk of adverse effects. Clinical data are scarce.
What this interaction means in plain words
Duloxetine and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP2D6 inhibition by quinacrine reduces duloxetine clearance.
What to do
Monitor for duloxetine adverse effects such as nausea, dizziness and agitation, and lower the dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Quinacrine?
MediHelp rates the interaction as moderate. Duloxetine and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinacrine may inhibit CYP2D6, which participates in duloxetine metabolism. Duloxetine levels could therefore increase, raising the risk of adverse effects. Clinical data are scarce.
How serious is the interaction between Duloxetine and Quinacrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects such as nausea, dizziness and agitation, and lower the dose if they occur.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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