Drug interactions
Duloxetine + Rifampin
Severity: Moderate
Duloxetine and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces drug-metabolizing enzymes including CYP1A2 and may lower duloxetine concentrations. This can reduce antidepressant or analgesic effect. It is not dangerous, so the combination is not contraindicated.
What this interaction means in plain words
Duloxetine and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP1A2 and other enzymes, increasing duloxetine clearance.
What to do
Monitor for loss of duloxetine efficacy and increase the dose if needed. Reassess the dose after rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Rifampin?
MediHelp rates the interaction as moderate. Duloxetine and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces drug-metabolizing enzymes including CYP1A2 and may lower duloxetine concentrations. This can reduce antidepressant or analgesic effect. It is not dangerous, so the combination is not contraindicated.
How serious is the interaction between Duloxetine and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of duloxetine efficacy and increase the dose if needed. Reassess the dose after rifampin is stopped.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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