Drug interactions
Duloxetine + Salsalate
Severity: Moderate
Duloxetine and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID that can contribute to GI bleeding risk, and duloxetine adds to this by impairing platelet function. The combination is more likely to cause bleeding than either drug alone.
What this interaction means in plain words
Duloxetine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Platelet serotonin depletion from duloxetine plus salicylate-related prostaglandin inhibition and mucosal injury.
What to do
Monitor for GI bleeding signs and use the lowest effective salsalate dose. Consider a proton pump inhibitor in patients at high risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Salsalate?
MediHelp rates the interaction as moderate. Duloxetine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID that can contribute to GI bleeding risk, and duloxetine adds to this by impairing platelet function. The combination is more likely to cause bleeding than either drug alone.
How serious is the interaction between Duloxetine and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding signs and use the lowest effective salsalate dose. Consider a proton pump inhibitor in patients at high risk.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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