Drug interactions
Duloxetine + Same
Severity: Moderate
Duloxetine and Same: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) supplements may increase serotonergic activity and have been associated with serotonin syndrome in case reports when combined with antidepressants. Duloxetine raises serotonin by reuptake inhibition, so the combination may add risk.
What this interaction means in plain words
Duloxetine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects; SAMe may increase monoamine synthesis.
What to do
Avoid starting SAMe in patients on duloxetine unless supervised. Monitor for agitation, tremor, sweating and hyperthermia if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Same?
MediHelp rates the interaction as moderate. Duloxetine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine (SAMe) supplements may increase serotonergic activity and have been associated with serotonin syndrome in case reports when combined with antidepressants. Duloxetine raises serotonin by reuptake inhibition, so the combination may add risk.
How serious is the interaction between Duloxetine and Same?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting SAMe in patients on duloxetine unless supervised. Monitor for agitation, tremor, sweating and hyperthermia if used together.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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