Drug interactions
Duloxetine + Selegiline transdermal
Severity: Contraindicated
Duloxetine and Selegiline transdermal: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO inhibitor, and its transdermal form is labeled as contraindicated with SNRIs because of the risk of serotonin syndrome and hypertensive crisis. Reactions can be severe and potentially fatal.
What this interaction means in plain words
Duloxetine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition by selegiline combined with serotonin and norepinephrine reuptake inhibition by duloxetine.
What to do
Do not combine. Stop duloxetine at least 5 days before starting selegiline, and wait at least 14 days after stopping selegiline before starting duloxetine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Duloxetine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is an MAO inhibitor, and its transdermal form is labeled as contraindicated with SNRIs because of the risk of serotonin syndrome and hypertensive crisis. Reactions can be severe and potentially fatal.
How serious is the interaction between Duloxetine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Stop duloxetine at least 5 days before starting selegiline, and wait at least 14 days after stopping selegiline before starting duloxetine.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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