Drug interactions
Duloxetine + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Duloxetine and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine can cause hyponatremia through SIADH, and bowel preparations cause fluid and electrolyte shifts. Together, particularly in older patients or those on diuretics, the risk of significant hyponatremia and dehydration may increase.
What this interaction means in plain words
Duloxetine and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on sodium and water balance from SIADH-type effects and osmotic bowel-prep fluid and electrolyte losses.
What to do
Ensure adequate hydration with the preparation and consider checking sodium beforehand in high-risk patients. Watch for confusion, headache or nausea after the prep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Duloxetine and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine can cause hyponatremia through SIADH, and bowel preparations cause fluid and electrolyte shifts. Together, particularly in older patients or those on diuretics, the risk of significant hyponatremia and dehydration may increase.
How serious is the interaction between Duloxetine and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration with the preparation and consider checking sodium beforehand in high-risk patients. Watch for confusion, headache or nausea after the prep.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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