Drug interactions
Duloxetine + Somatropin
Severity: Minor
Duloxetine and Somatropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase activity of some cytochrome P450 enzymes, including CYP1A2, which could lower duloxetine levels. Evidence is limited and the clinical effect is probably small.
What this interaction means in plain words
Duloxetine and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duloxetine belongs to Central Nervous System; Somatropin belongs to Endocrine.
Why it happens
Somatropin may induce CYP-mediated clearance, potentially increasing CYP1A2 metabolism of duloxetine.
What to do
No routine adjustment is needed; reassess duloxetine response if symptom control worsens after somatropin is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Duloxetine with Somatropin?
MediHelp rates the interaction as minor. Duloxetine and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase activity of some cytochrome P450 enzymes, including CYP1A2, which could lower duloxetine levels. Evidence is limited and the clinical effect is probably small.
How serious is the interaction between Duloxetine and Somatropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess duloxetine response if symptom control worsens after somatropin is started.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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