Drug interactions
Duloxetine + Sufentanil sl
Severity: Moderate
Duloxetine and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonin-norepinephrine reuptake inhibitor with an opioid that has some serotonergic activity can precipitate serotonin syndrome. Presentation includes agitation, tremor, clonus, hyperthermia and autonomic instability. The risk is highest at initiation and after dose increases.
What this interaction means in plain words
Duloxetine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from duloxetine reuptake inhibition and the opioid's weak serotonergic activity.
What to do
Monitor for features of serotonin toxicity, especially when starting or increasing doses. Stop one or both drugs if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Sufentanil sl?
MediHelp rates the interaction as moderate. Duloxetine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonin-norepinephrine reuptake inhibitor with an opioid that has some serotonergic activity can precipitate serotonin syndrome. Presentation includes agitation, tremor, clonus, hyperthermia and autonomic instability. The risk is highest at initiation and after dose increases.
How serious is the interaction between Duloxetine and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for features of serotonin toxicity, especially when starting or increasing doses. Stop one or both drugs if symptoms develop.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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